Synthetic peptide vaccine confers protection against murine malaria
نویسندگان
چکیده
A synthetic peptide, (DPPPPNPN)2D, representing a subunit of the repeat domain of the Plasmodium berghei circumsporozoite protein, was conjugated to tetanus toxoid using bisdiazobenzidine. Immunization of mice and rats with the conjugate induced high serum titers of antibodies to the parasite, and most of the animals were completely protected from malaria infection when challenged with sporozoites.
منابع مشابه
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ورودعنوان ژورنال:
- The Journal of Experimental Medicine
دوره 166 شماره
صفحات -
تاریخ انتشار 1987